Elemental analysis: Mineral compounds and trace elements

The elements are analyzed after microwave digestion by ICP-MS (inductively coupled plasma - mass spectrometry) or atomic absorption spectrometry.

For the quantitative analysis of the mineral compounds of sodium, potassion, calcium and magnesium, which usually occur in higher concentrations, atomic absorption spectrometry is the method of choice. In contrast, the trace elements iodine, selenium, zinc, chromium, molybdenum, and toxic heavy metals such as lead, cadmium and nickel, are determined using ICP-MS.
As a special service, we offer elemental screening using ICP-MS. This allows the semi-quantitative determination at trace level of almost all the metals and amphoteric elements – from boron, through the rare earth metals, to uranium. A sample amount of 100 mg is sufficient, and provides maximum information for minimum effort.
We determine "elemental impurities" in pharmaceutical products using ICP-MS after microwave digestion according to EMEA Guideline (EMEA/CHMP/SWAP/4446/2000, effective from September 2013) and USP chapters <232> and <233> (effective from December 2012). This analysis method will replace the limit testing in U.S. Pharmacopoeia in May 2014.

We advise you and support the creation of an individual test plan depending on the manufacturing process, the dosage form, or other requirements.

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